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Breast Neoplasm, Unilateral

MedGen UID:
866340
•Concept ID:
C4018978
•
Neoplastic Process
Synonyms: Breast Cancer, Unilateral; Breast Cancers, Unilateral; Breast Neoplasms, Unilateral; Unilateral Breast Cancer; Unilateral Breast Cancers; Unilateral Breast Neoplasms

Definition

Tumors or cancer found specifically in one human BREAST, but not in both. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Neoplasm, Unilateral

Professional guidelines

PubMed

Update on the clinical management of multiple endocrine neoplasia type 1.
Pieterman CRC, Valk GD
Clin Endocrinol (Oxf) 2022 Oct;97(4):409-423. Epub 2022 Apr 1 doi: 10.1111/cen.14727. PMID: 35319130Free PMC Article
Imaging Surveillance After Primary Breast Cancer Treatment.
Lam DL, Houssami N, Lee JM
AJR Am J Roentgenol 2017 Mar;208(3):676-686. Epub 2017 Jan 11 doi: 10.2214/AJR.16.16300. PMID: 28075622Free PMC Article
Contouring Guidelines for the Axillary Lymph Nodes for the Delivery of Radiation Therapy in Breast Cancer: Evaluation of the RTOG Breast Cancer Atlas.
Gentile MS, Usman AA, Neuschler EI, Sathiaseelan V, Hayes JP, Small W Jr
Int J Radiat Oncol Biol Phys 2015 Oct 1;93(2):257-65. Epub 2015 Aug 6 doi: 10.1016/j.ijrobp.2015.07.002. PMID: 26383674

Recent clinical studies

Etiology

EBCC-13 manifesto: Balancing pros and cons for contralateral prophylactic mastectomy.
Schmidt MK, Kelly JE, Brédart A, Cameron DA, de Boniface J, Easton DF, Offersen BV, Poulakaki F, Rubio IT, Sardanelli F, Schmutzler R, Spanic T, Weigelt B, Rutgers EJT
Eur J Cancer 2023 Mar;181:79-91. Epub 2022 Dec 13 doi: 10.1016/j.ejca.2022.11.036. PMID: 36641897Free PMC Article
Bilateral Mastectomy in Women With Unilateral Breast Cancer: A Review.
Lim DW, Metcalfe KA, Narod SA
JAMA Surg 2021 Jun 1;156(6):569-576. doi: 10.1001/jamasurg.2020.6664. PMID: 33566074
Risk-reducing mastectomy for the prevention of primary breast cancer.
Carbine NE, Lostumbo L, Wallace J, Ko H
Cochrane Database Syst Rev 2018 Apr 5;4(4):CD002748. doi: 10.1002/14651858.CD002748.pub4. PMID: 29620792Free PMC Article
Why Are There So Many Mastectomies in the United States?
Mamtani A, Morrow M
Annu Rev Med 2017 Jan 14;68:229-241. Epub 2016 Aug 26 doi: 10.1146/annurev-med-043015-075227. PMID: 27576011
Contouring Guidelines for the Axillary Lymph Nodes for the Delivery of Radiation Therapy in Breast Cancer: Evaluation of the RTOG Breast Cancer Atlas.
Gentile MS, Usman AA, Neuschler EI, Sathiaseelan V, Hayes JP, Small W Jr
Int J Radiat Oncol Biol Phys 2015 Oct 1;93(2):257-65. Epub 2015 Aug 6 doi: 10.1016/j.ijrobp.2015.07.002. PMID: 26383674

Diagnosis

Diffuse unilateral MRI breast entities.
Sivarajah RT, Bean TR, Chetlen AL
Clin Imaging 2024 Nov;115:110305. Epub 2024 Sep 23 doi: 10.1016/j.clinimag.2024.110305. PMID: 39342818
EBCC-13 manifesto: Balancing pros and cons for contralateral prophylactic mastectomy.
Schmidt MK, Kelly JE, Brédart A, Cameron DA, de Boniface J, Easton DF, Offersen BV, Poulakaki F, Rubio IT, Sardanelli F, Schmutzler R, Spanic T, Weigelt B, Rutgers EJT
Eur J Cancer 2023 Mar;181:79-91. Epub 2022 Dec 13 doi: 10.1016/j.ejca.2022.11.036. PMID: 36641897Free PMC Article
Radiation doses and fractionation schedules in non-low-risk ductal carcinoma in situ in the breast (BIG 3-07/TROG 07.01): a randomised, factorial, multicentre, open-label, phase 3 study.
Chua BH, Link EK, Kunkler IH, Whelan TJ, Westenberg AH, Gruber G, Bryant G, Ahern V, Purohit K, Graham PH, Akra M, McArdle O, O'Brien P, Harvey JA, Kirkove C, Maduro JH, Campbell ID, Delaney GP, Martin JD, Vu TTT, Muanza TM, Neal A, Olivotto IA; BIG 3–07/TROG 07.01 trial investigators
Lancet 2022 Aug 6;400(10350):431-440. doi: 10.1016/S0140-6736(22)01246-6. PMID: 35934006
Contouring Guidelines for the Axillary Lymph Nodes for the Delivery of Radiation Therapy in Breast Cancer: Evaluation of the RTOG Breast Cancer Atlas.
Gentile MS, Usman AA, Neuschler EI, Sathiaseelan V, Hayes JP, Small W Jr
Int J Radiat Oncol Biol Phys 2015 Oct 1;93(2):257-65. Epub 2015 Aug 6 doi: 10.1016/j.ijrobp.2015.07.002. PMID: 26383674
Bilateral breast cancers.
Narod SA
Nat Rev Clin Oncol 2014 Mar;11(3):157-66. Epub 2014 Feb 4 doi: 10.1038/nrclinonc.2014.3. PMID: 24492834

Therapy

Radiation doses and fractionation schedules in non-low-risk ductal carcinoma in situ in the breast (BIG 3-07/TROG 07.01): a randomised, factorial, multicentre, open-label, phase 3 study.
Chua BH, Link EK, Kunkler IH, Whelan TJ, Westenberg AH, Gruber G, Bryant G, Ahern V, Purohit K, Graham PH, Akra M, McArdle O, O'Brien P, Harvey JA, Kirkove C, Maduro JH, Campbell ID, Delaney GP, Martin JD, Vu TTT, Muanza TM, Neal A, Olivotto IA; BIG 3–07/TROG 07.01 trial investigators
Lancet 2022 Aug 6;400(10350):431-440. doi: 10.1016/S0140-6736(22)01246-6. PMID: 35934006
Effect of exercise mode on physical function and quality of life in breast cancer-related lymphedema: a randomized trial.
Basha MA, Aboelnour NH, Alsharidah AS, Kamel FH
Support Care Cancer 2022 Mar;30(3):2101-2110. Epub 2021 Oct 20 doi: 10.1007/s00520-021-06559-1. PMID: 34669036
Risk-reducing mastectomy for the prevention of primary breast cancer.
Carbine NE, Lostumbo L, Wallace J, Ko H
Cochrane Database Syst Rev 2018 Apr 5;4(4):CD002748. doi: 10.1002/14651858.CD002748.pub4. PMID: 29620792Free PMC Article
Efficacy of Chemotherapy for ER-Negative and ER-Positive Isolated Locoregional Recurrence of Breast Cancer: Final Analysis of the CALOR Trial.
Wapnir IL, Price KN, Anderson SJ, Robidoux A, Martín M, Nortier JWR, Paterson AHG, Rimawi MF, Láng I, Baena-Cañada JM, Thürlimann B, Mamounas EP, Geyer CE Jr, Gelber S, Coates AS, Gelber RD, Rastogi P, Regan MM, Wolmark N, Aebi S; International Breast Cancer Study Group; NRG Oncology, GEICAM Spanish Breast Cancer Group, BOOG Dutch Breast Cancer Trialists' Group; Breast International Group
J Clin Oncol 2018 Apr 10;36(11):1073-1079. Epub 2018 Feb 14 doi: 10.1200/JCO.2017.76.5719. PMID: 29443653Free PMC Article
Chemotherapy for isolated locoregional recurrence of breast cancer (CALOR): a randomised trial.
Aebi S, Gelber S, Anderson SJ, Láng I, Robidoux A, Martín M, Nortier JW, Paterson AH, Rimawi MF, Cañada JM, Thürlimann B, Murray E, Mamounas EP, Geyer CE Jr, Price KN, Coates AS, Gelber RD, Rastogi P, Wolmark N, Wapnir IL; CALOR investigators
Lancet Oncol 2014 Feb;15(2):156-63. Epub 2014 Jan 16 doi: 10.1016/S1470-2045(13)70589-8. PMID: 24439313Free PMC Article

Prognosis

Second Primary Breast Cancer in Young Breast Cancer Survivors.
Brantley KD, Rosenberg SM, Collins LC, Ruddy KJ, Tamimi RM, Schapira L, Borges VF, Warner E, Come SE, Zheng Y, Kirkner GJ, Snow C, Winer EP, Partridge AH
JAMA Oncol 2024 Jun 1;10(6):718-725. doi: 10.1001/jamaoncol.2024.0286. PMID: 38602683Free PMC Article
Age-Related Incidence and Peak Occurrence of Contralateral Breast Cancer.
Kim H, Yoon TI, Kim S, Lee SB, Kim J, Chung IY, Ko BS, Lee JW, Son BH, Lee YJ, Gwark S, Kim HJ
JAMA Netw Open 2023 Dec 1;6(12):e2347511. doi: 10.1001/jamanetworkopen.2023.47511. PMID: 38100108Free PMC Article
EBCC-13 manifesto: Balancing pros and cons for contralateral prophylactic mastectomy.
Schmidt MK, Kelly JE, Brédart A, Cameron DA, de Boniface J, Easton DF, Offersen BV, Poulakaki F, Rubio IT, Sardanelli F, Schmutzler R, Spanic T, Weigelt B, Rutgers EJT
Eur J Cancer 2023 Mar;181:79-91. Epub 2022 Dec 13 doi: 10.1016/j.ejca.2022.11.036. PMID: 36641897Free PMC Article
Extent of Surgery and the Prognosis of Unilateral Papillary Thyroid Microcarcinoma.
Zhao H, Cui L
Front Endocrinol (Lausanne) 2021;12:655608. Epub 2021 Jun 16 doi: 10.3389/fendo.2021.655608. PMID: 34220708Free PMC Article
Chemotherapy for isolated locoregional recurrence of breast cancer (CALOR): a randomised trial.
Aebi S, Gelber S, Anderson SJ, Láng I, Robidoux A, Martín M, Nortier JW, Paterson AH, Rimawi MF, Cañada JM, Thürlimann B, Murray E, Mamounas EP, Geyer CE Jr, Price KN, Coates AS, Gelber RD, Rastogi P, Wolmark N, Wapnir IL; CALOR investigators
Lancet Oncol 2014 Feb;15(2):156-63. Epub 2014 Jan 16 doi: 10.1016/S1470-2045(13)70589-8. PMID: 24439313Free PMC Article

Clinical prediction guides

Clinical Features and Prognoses of Patients With Breast Cancer Who Underwent Surgery.
Liu G, Kong X, Dai Q, Cheng H, Wang J, Gao J, Wang Y
JAMA Netw Open 2023 Aug 1;6(8):e2331078. doi: 10.1001/jamanetworkopen.2023.31078. PMID: 37624596Free PMC Article
Bilateral Mastectomy in Women With Unilateral Breast Cancer: A Review.
Lim DW, Metcalfe KA, Narod SA
JAMA Surg 2021 Jun 1;156(6):569-576. doi: 10.1001/jamasurg.2020.6664. PMID: 33566074
Association of Breast Cancer Surgery With Quality of Life and Psychosocial Well-being in Young Breast Cancer Survivors.
Rosenberg SM, Dominici LS, Gelber S, Poorvu PD, Ruddy KJ, Wong JS, Tamimi RM, Schapira L, Come S, Peppercorn JM, Borges VF, Partridge AH
JAMA Surg 2020 Nov 1;155(11):1035-1042. doi: 10.1001/jamasurg.2020.3325. PMID: 32936216Free PMC Article
Risk-reducing mastectomy for the prevention of primary breast cancer.
Carbine NE, Lostumbo L, Wallace J, Ko H
Cochrane Database Syst Rev 2018 Apr 5;4(4):CD002748. doi: 10.1002/14651858.CD002748.pub4. PMID: 29620792Free PMC Article
Efficacy of Chemotherapy for ER-Negative and ER-Positive Isolated Locoregional Recurrence of Breast Cancer: Final Analysis of the CALOR Trial.
Wapnir IL, Price KN, Anderson SJ, Robidoux A, Martín M, Nortier JWR, Paterson AHG, Rimawi MF, Láng I, Baena-Cañada JM, Thürlimann B, Mamounas EP, Geyer CE Jr, Gelber S, Coates AS, Gelber RD, Rastogi P, Regan MM, Wolmark N, Aebi S; International Breast Cancer Study Group; NRG Oncology, GEICAM Spanish Breast Cancer Group, BOOG Dutch Breast Cancer Trialists' Group; Breast International Group
J Clin Oncol 2018 Apr 10;36(11):1073-1079. Epub 2018 Feb 14 doi: 10.1200/JCO.2017.76.5719. PMID: 29443653Free PMC Article

Recent systematic reviews

Risk factors of unilateral breast cancer-related lymphedema: an updated systematic review and meta-analysis of 84 cohort studies.
Shen A, Lu Q, Fu X, Wei X, Zhang L, Bian J, Qiang W, Pang D
Support Care Cancer 2022 Dec 14;31(1):18. doi: 10.1007/s00520-022-07508-2. PMID: 36513801
Risk-reducing mastectomy for the prevention of primary breast cancer.
Carbine NE, Lostumbo L, Wallace J, Ko H
Cochrane Database Syst Rev 2018 Apr 5;4(4):CD002748. doi: 10.1002/14651858.CD002748.pub4. PMID: 29620792Free PMC Article
BRCA1/2 Mutation-associated Breast Cancer, Wide Local Excision and Radiotherapy or Unilateral Mastectomy: A Systematic Review.
Hallam S, Govindarajulu S, Huckett B, Bahl A
Clin Oncol (R Coll Radiol) 2015 Sep;27(9):527-35. Epub 2015 Jun 22 doi: 10.1016/j.clon.2015.06.001. PMID: 26113392
Contralateral prophylactic mastectomy after unilateral breast cancer: a systematic review and meta-analysis.
Fayanju OM, Stoll CR, Fowler S, Colditz GA, Margenthaler JA
Ann Surg 2014 Dec;260(6):1000-10. doi: 10.1097/SLA.0000000000000769. PMID: 24950272Free PMC Article
Incidence of unilateral arm lymphoedema after breast cancer: a systematic review and meta-analysis.
DiSipio T, Rye S, Newman B, Hayes S
Lancet Oncol 2013 May;14(6):500-15. Epub 2013 Mar 27 doi: 10.1016/S1470-2045(13)70076-7. PMID: 23540561

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